[VIDEO] Pfizer-Biontech COVID-19 mRNA Vaccine Explained

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Uploaded: 11 Nov 2020 (6 years ago) · Shared: 24 Nov 2020

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Professor Roger Seheult, MD discusses the Pfizer / Biontech COVID-19 mRNA vaccine: How it works and what we know about the safety and efficacy at this time. No mRNA vaccine has ever been approved

by the FDA, but Pfizer and BioNTech hope to receive emergency approval based on preliminary data from their ongoing vaccine trial.

This two-dose vaccine regimen has limitations including the need for -70 C refrigeration and many questions remain:
Will the vaccine prevent transmission and asymptomatic spread?
How long will immunity last?
Will “90% effective” hold up to peer-review and additional data when it is gathered?

(This video was recorded on November 12, 2020).

Dr. Seheult is the co-founder and lead instructor at https://www.medcram.com

LINKS / REFERENCES:

Johns Hopkins Tracker | https://coronavirus.jhu.edu/map.html

Worldometer | https://www.worldometers.info/coronavirus/

COVID-19 vaccine tracker (RAPS) | https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates (NEJM) | https://www.nejm.org/doi/full/10.1056/NEJMoa2027906

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates (bioRxiv) | https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1.full.pdf

Pfizer and BioNTech Announce Vaccine Candidate Against COVID-19 Achieved Success in First Interim Analysis from Phase 3 Study (BioNTech) | https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-announce-vaccine-candidate-against-covid-19

Why mRNA represents a disruptive new drug class {BioNTech) | https://biontech.de/how-we-translate/mrna-therapeutics

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Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Associate Professor at the University of California, Riverside School of Medicine

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Topics with MedCram, mRNA, Vaccine (3)

Who are MedCram? MedCram offers a dramatically more efficient, engaging, fun, and lasting way to learn and review medical topics. MedCram was founded in 2012 by Dr. Roger Seheult and one of his former PA students, Kyle Allred, with one word in mind: CLARITY.
What is mRNA? mRNA or messenger RNA, in molecular biology is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. During transcription, RNA polymerase makes a copy of a gene from the DNA to mRNA as needed. This process is slightly different in eukaryotes and prokaryotes, including that prokaryotic RNA polymerase associates with DNA-processing enzymes during transcription so that processing can proceed during transcription. As in DNA, genetic information in mRNA is contained in the sequence of nucleotides, which are arranged into codons consisting of three base pairs each. Each codon codes for a specific amino acid, except the stop codons, which terminate protein synthesis. The translation of codons into amino acids requires two other types of RNA: transfer RNA, which recognizes the codon and provides the corresponding amino acid, and ribosomal RNA (rRNA), the central component of the ribosome's protein-manufacturing machinery.
What is Vaccine? A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. The administration of vaccines is called vaccination. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world.

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3.Trump: Covid-19 will 'go away without a Vaccine' \| The Guardian
4.Gates Foundation calls for global cooperation on Vaccine for 7 Billion people \| Malay Mail
5.Saudi Arabia pledges $150 million to GAVI to develop a Coronavirus vaccine, supported by Bill & Melina Gates Foundation \| Arab News
6.Trump says he would mobilize US Military to distribute Coronavirus Vaccine \| CBS
7.Trust Stamp: Africa to roll-out 'Biometric ID' Vaccine & Cashless System \| Mintpress
8.TrustNet Pakistan with CovidCreds develops blockchain digital COVID passport to prove Vaccination \| Techjuice
9.Trump: Coronavirus vaccine may be made mandatory by State governors \| Natural News
10.Australia, Victoria: No access to Restaurants, Businesses or Childcare if you refuse Coronavirus vaccine \| Natural News
11.Bill Gates: World needs 14 billion doses of a Coronavirus vaccine \| Business Insider
12.Bill Gates: Multiple vaccine doses could be necessary to protect from Coronavirus \| CBS
13.Coronavirus 'disappearing' so fast Oxford vaccine has 'only 50% chance of working' \| Sky News
14.COVID Vaccine, INO-4800 to inject DNA into Human Cells to trigger response against SARS-CoV-2 \| Times of Israel
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17.Saudi Arabia and UAE to test Russia's Sputnik-V Coronavirus Vaccine \| Bloomberg
18.Australia wants 95% uptake of 'voluntary' Coronavirus vaccine \| The Guardian
19.Canada: Social distancing, Face masks may continue till 2023, even with a Coronavirus vaccine, Tam warns \| CBC
20.USA, Massachusetts orders Flu Vaccination mandatory for Babies aged from 6 months \| Forbes
21.UK: Hancock hints Coronavirus vaccine could be mandatory \| Metro
22.Australia: Refuse the Coronavirus vaccine, you may lose your Job \| Mail Online
23.Pope Francis backs Bill Gates in his 'universal plans' to COVID vaccinate the entire World \| LifeSite
24.Open consultation: UK government to be advised on allowing an 'unlicensed' COVID-19 vaccine on public health grounds \| GOV.UK
25.Ipsos MORI Poll: 33% of Americans say NO to a COVID-19 vaccine \| Business Insider
26.British Army to help NHS deliver Coronavirus vaccination to 67 million people \| inews
27.Anyone refusing Vaccine becomes the 'weak link' that allows Coronavirus to spread, Pfizer CEO says \| CNBC
28.Egypt to test Chinese Coronavirus Vaccine on 6,000 volunteers, backed by China and UAE technology company \| New Arab
29.Even with COVID Vaccine, Face Masks and Social Distancing will continue for years \| The National AE
30.We'll Be Wearing Face Masks In 2021, Even With A COVID-19 Vaccine \| Huffington
31.UAE, Dubai: Face Masks must be worn in public until 66% of population take the COVID vaccine \| The National AE
32.Americans to be 'forced' to take mandatory COVID Vaccine, or incur penalty \| RT News
33.UAE praises 'deep friendship' with China, especially their COVID vaccine partnership with Sinopharm, Chinese drug maker \| The National AE
34.AstraZeneca COVID Vaccine trial 'on-hold' in US after volunteers suffer serious Neurological illnesses \| Mirror
35.Australian Police can legally remove your Underwear to vaccinate you, in COVID emergency \| LifeSite
36.95% of Australians targeted for Oxford COVID Vaccine \| The Guardian
37.Australia PM: COVID vaccine likely to be mandatory \| ABC
38.Volunteer dies in AstraZeneca/Oxford University COVID-19 vaccine trial \| Express
39.Transhuman: Will a DARPA-Funded Microchip Implant with mRNA heal COVID-19? \| David Icke
40.Google & Oracle to track Americans who take COVID-19 Vaccine upto 2 Years \| TLAV
41.Millions of people do not need a COVID vaccine, Mike Yeadon writes \| Lockdown Sceptics
42.Moderna lands US COVID-19 vaccine mRNA-1273 contract worth up to $8bn \| BioPharma-Reporter
43.Moderna Awarded $8bn Contract to deliver 500 Million doses of COVID-19 mRNA-1273 vaccine (100mg) to US Government \| headlineswithavoice
44.WHO confronts online Conspiracy Theories to influence COVID Vaccine discussion \| Off-Guardian
45.Jordan expects COVID-19 Vaccine in early 2021 \| Roya News
46.UK Government give 'serious consideration' to mandatory COVID-19 vaccine \| Parliament Committee
47.Employers may block Employees who refuse COVID Vaccination \| Huffington
48.Anti-vaxxers could be banned from Restaurants, Pubs, Work and Offices if they refuse COVID Vaccine \| Metro
49.COVID Face Masks and Social Distancing will stay even after Vaccine is available, says Anthony Fauci \| NTEB
50.US Government 'must get people to take the COVID Vaccine', says Anthony Fauci \| RT News
51.Israel Government will not make COVID Vaccine mandatory. Amazon will. Airlines will. Banks will \| Arutz Sheva
52.Experimental mRNA vaccines arrive as COVID pandemic rages \| Medical Xpress
53.mRNA COVID Vaccines deliver Genetic Code to our Cells \| TheScientist
54.Pfizer-BioNTech BNT162b2 mRNA COVID-19 Vaccine Information Notes for UK Healthcare Professionals (PDF) \| GOV.UK
55.mRNA Vaccines Clinically Unproven. Untested in large-scale human trials \| JAMA Network
56.UK Army 77th Brigade to take on anti-COVID Vaccine militants \| The Times
57.British Army spies wage 'information war' against anti-COVID Vaccine content online - report \| RT News
58.UAE to be a central distribution center for global COVID Vaccine distributions \| The National
59.Pfizer seeks emergency use of COVID-19 mRNA vaccine in India \| Mint
60.COVID-19 Vaccine Frontrunners and Their Nanotechnology Design \| NCBI
61.Israel: 'Green Passport' for anyone who takes COVID Vaccine to ease lockdown restrictions \| Times of Israel
62.The COVID-19 recovery can be the vaccine for climate change \| World Economic Forum
63.Egypt's Scholars say having COVID vaccine is Islamic duty \| Middle East Eye
64.AD Bank launches $9 billion COVID vaccine facility to help developing countries in Asia \| World Economic Forum
65.Saudi Arabia opens registration for mRNA Pfizer-BioNTech Covid vaccine \| The National
66.Mexico approves emergency use of Pfizer mRNA COVID-19 vaccine \| YeniSafak
67.Brazil's supreme court rules Covid vaccine can be mandatory \| Telegraph
68.myGP to launch digital UK COVID-19 vaccination verification for smartphones \| myGP
69.Ireland: COVID Vaccine Health Certificates part of implementation plan, says Donnelly \| Irish Times
70.Pope Francis urges Coronavirus Vaccine access for everyone in world \| BBC News
71.Vatican: Catholics can take COVID Vaccine using aborted Baby Cells \| New American
72.Davos Global Agenda 2021: COVID Vaccination, Jobs & Climate Change \| World Economic Forum
73.Saudi Arabia, UAE, Kuwait, Bahrain, Qatar, Oman signup to mRNA Pfizer-Biontech COVID vaccine \| Middle East Eye
74.Saudi Arabia, Jeddah aims to give COVID Vaccine to 10,000 people a day \| Arab News
75.China approves Sinopharm COVID-19 vaccine for 50M people \| Business Insider
76.Pakistan to buy 1.2M COVID-19 vaccine doses from China's Sinopharm \| Reuters
77.UAE to cold-store mRNA COVID Vaccines for poorer countries \| The National
78.We may need to repeat COVID Vaccine every 6 months, UK health secretary warns \| RT News
79.Kuwait: Schools to open after 65% of population take mRNA Pfizer-Biontech COVID Vaccine \| MEMO
80.India: Oxford-Astrazeneca COVID vaccine approved with 50M doses ready \| Telegraph
81.USA, California dentists can administer COVID Vaccine \| Business Insider
82.mRNA Medicines: Our Operating System \| moderna
83.Brazil PM says he will REFUSE to take COVID-19 Vaccine \| The Sun
84.Covid-19 vaccination is NOT mandatory. No one pressured to receive vaccine \| Council Of Europe
85.It's Gene Therapy, Not a COVID Vaccine \| Weston A Price
86.Indonesia to give COVID Vaccine to young first, 67% population or 181.5 Million people \| World Economic Forum
87.Spain to register details of people refusing COVID Vaccine, to share with EU Countries \| BBC News
88.Algeria launches COVID vaccination with Russian Sputnik V \| France24
89.DARPA funded microchip implant may be used to deploy Moderna mRNA vaccine \| Nanotechnology
90.Abu Dhabi encourages free, voluntary COVID vaccine by listing social benefits \| The National
91.Pakistan begins vaccinations with Chinese Sinopharm COVID vaccine \| The National
92.Bahrain launches digital COVID-19 vaccine health passport \| Arab News
93.Indonesia: $350 fine for refusing mandatory COVID vaccine \| Arab News
94.46 residents in Spanish Care Home die after receiving COVID-19 vaccine \| LifeSite
95.Saudi Arabia: Hajj worshippers must have COVID-19 vaccine to visit \| Roya News
96.MINDSPACE NHS Behavioural Change: Optimizing Vaccine Rollout (PDF) \| UK GOV
97.Israelis may need new Pfizer/Moderna vaccine every 6 months \| Arutz Sheva
98.US Biden announces April 19 deadline to make ALL Adults eligible for Covid vaccine \| NBC News
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100.People should prepare for a Covid Vaccine injection every year \| NTEB
101.Saudi Arabia approves Moderna COVID Vaccine for children aged 6 years old \| The National
102.Taiwan recommends high-risk groups take COVID vaccine jab every 60 days \| Taiwan News

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Pfizer-Biontech COVID-19 mRNA Vaccine Explained - MedCram

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