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COVID-19 vaccination, all-cause mortality, and hospitalization for cancer: 30-month cohort study in an Italian province
https://pubmed.ncbi.nlm.nih.gov/40881928/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12381369/
https://www.thefocalpoints.com/p/breaking-first-population-wide-study
The rate of first hospitalization for cancer of any site
Unvaccinated group: 0.85%
Vaccinated group (one or more doses): 1.15%
N = 296,015 population
Hospital admission with a cancer diagnosis, 3,124
(p less than 0.001).
Vaccination with at least one dose
Colon-rectal cancer HR: 1.34
Breast cancer HR: 1.54
Bladder cancer HR: 1.62
After three or more vaccine doses
Breast cancer HR: 1.36
Bladder cancer HR: 1.43
All significant
After one dose (180 days after)
Rate of first hospital admissions for cancers
All cancers: up 23% significant
Colorectal: up 34% significant
Lung: down = 10%
Breast: up 54% significant
Uterine: up = 75%
Ovarian: up = 65%
Prostate: up = 1%
Bladder: up 62% significant
Thyroid: up =58%
Haematological: up = 33%
After three dose (180 days after administration of third dose)
All cancers: up = 9%
Colorectal: up = 14%
Lung: down = 5%
Breast: up=36% significant
Uterine: up = 20%
Ovarian: up = 86%
Prostate: down = 3%
Bladder: up=43% significant
Thyroid: down = 3%
Haematological: up = 5%
More about the study
Population-wide cohort analysis
Evaluating the risk of all-cause death and cancer hospitalization by SARS-CoV-2 immunization status.
National Health System official data, entire population, Pescara province, Italy
Followed from June 2021 (six months after the first vaccination) to December 2023.
296,015 residents aged ≥11 years
Hospital admission with a cancer diagnosis, 3,124
16.6% were unvaccinated
83.3% received ≥1 dose
62.2% ≥3 doses.
Compared with the unvaccinated, those receiving ≥1 dose showed a significantly lower likelihood of all-cause death
Cancer hospitalization was significant only among the subjects with no previous SARS-CoV-2 infection
Some cancer risks went down after 1 year (relative to 180 days)
(But breast, ovarian and bladder went up at one year relative to 180 days after 1 vaccine dose)
Given that it was not possible to quantify the potential impact of the healthy vaccinee bias and unmeasured confounders, these findings are inevitably preliminary.
Published: 05 Sep 2025 ·
Uploaded: 15 Apr 2026
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