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https://www.sciencenews.org/article/crispr-gene-editor-first-human-clinical-trialsPublished by: SCIENCENEWS on 14 Aug 2019
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The gene editor targets cancer, blood disorders and blindness CUTTING ROOM Scientists will soon wield the molecular scissors CRISPR/Cas9 in the human body. Some people with a form of inherited blindness will have the gene editor injected into their eyes, where researchers hope it will snip out amutation. Two other trials are CRISPR editing cells outside of the body to treat cancer or blood disorders.
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By Tina Hesman Saey
August 14, 2019 at 8:00 am - More than 2 years ago
Since its debut in 2012, CRISPR gene
editing has held the promise of curing most of the over 6,000 known genetic
diseases. Now it’s being put to the test.
In the first spate of clinical trials, scientists
are using CRISPR/Cas9 to combat cancer and blood disorders in people. In these
tests, researchers remove some of a person’s cells, edit the DNA and then inject
the cells back in, now hopefully armed to fight disease.
Researchers are also set to see how
CRISPR/Cas9 works [...]
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What is Science?Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. The earliest roots of science can be traced to the works of Ancient Egyptians and Mesopotamians, whose contributions entered and shaped Greek natural philosophy of classical antiquity. After the fall of the Western Roman Empire, knowledge of Greek science deteriorated in Western Europe during the Middle Ages but flourished in the Islamic Golden Age. Modern science is typically divided into three major branches that consist of the natural sciences (e.g. biology, chemistry, physics), which study nature in the broadest sense; the social sciences (e.g. psychology, sociology, economics), which study individuals and societies; and the formal sciences (e.g. mathematics, logic, theoretical computer science), which study abstract concepts.
What is CRISPR?CRISPR (clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. CRISPR technology is a simple yet powerful tool for editing genomes. It allows researchers to easily alter DNA sequences and modify gene function. Its many potential applications include correcting genetic defects, treating and preventing the spread of diseases and improving crops.
